2018

Imprinted maternally-expressed microRNAs antagonize paternally-driven gene programs in neurons. Whipple AJ, Jacobs HN, Breton-Provencher V, Sur M, Sharp PA. bioRxiv

Transcriptome alterations in myotonic dystrophy skeletal muscle and heart. Wang ET, Treacy D, Eichinger K, Struck A, Estabrook J, Olafson H, Wang TT, Bhatt K, Westbrook T, Sedehizadeh S, Ward AJ, Day J, Brook D, Berglund JA, Cooper T, Housman D, Thornton C, & Burge C. Hum Mol Genet, 2018. PubMed


2017

Disrupted neuronal maturation in Angelman syndrome-derived induced pluripotent stem cells. Fink JJ, Robinson TM, Germain ND, Sirois CL, Bolduc KA, Ward AJ, Rigo F, Chamberlain SJ, & Levine ES. Nat Commun, 2017. PubMed

The antisense transcript SMN-AS1 regulates SMN expression and is a novel therapeutic target for spinal muscular atrophy. d’Ydewalle C, Ramos DM, Pyles NJ, Ng SY, Gorz M, Pilato CM, King K, Kong L, Ward AJ, Rubin LL, Rigo F, Bennett CF, & Sumner CJ. Neuron, 2017. PubMed


2015

Antagonistic regulation of mRNA expression and splicing by CELF and MBNL proteins. Wang ET, Ward AJ, Cherone J, Wang TT, Giudice J, Treacy D, Freese P, Lambert NJ, Saxena T, Cooper TA, & Burge CB. Genome Res, 2015. PubMed

Towards a therapy for Angelman syndrome by targeting a long non-coding RNA. Meng L*, Ward AJ*, Chun S, Bennett CF, Beaudet AL, & Rigo F. Nature, 2015. PubMed

Comment in: Neurodevelopmental disorders: Unmuting Ube3a in mice alleviates Angelman syndrome. Malkki H. Nat Rev Neurol, 2015. PubMed


2014

LincRNA-p21 activates p21 in cis to promote polycomb target gene expression and to enforce the G1/S checkpoint. Dimitrova N, Zamudio J, Jong RM, Soukup D, Resnick R, Sarma K, Ward AJ, Raj A, Lee J, Sharp P, & Jacks T. Mol Cell, 2014. PubMed

Nonsense-mediated decay as a terminating mechanism for antisense oligonucleotides. Ward AJ, Norrbom M, Chun S, Bennett CF, & Rigo F. Nucleic Acids Res, 2014. PubMed

Alternative splicing regulates vesicular trafficking genes in cardiomyocytes during postnatal heart development. Giudice J, Xia Z, Wang ET, Scavuzzo MA, Ward AJ, Kalsotra A, Wang W, Wehrens XH, Burge CB, Li W, & Cooper TA. Nat Commun, 2014. PubMed

The Mef2 transcriptional network is disrupted in myotonic dystrophy heart tissue dramatically altering miRNA and mRNA expression. Kalsotra A, Singh RK, Gurha P, Ward AJ, Creighton CJ, & Cooper TA. Cell Rep, 2014. PubMed


2011

Alternative splicing misregulation secondary to skeletal muscle regeneration. Orengo JP*, Ward AJ*, & Cooper TA. Ann Neurol, 2011. PubMed


2010

CUGBP1 overexpression in mouse skeletal muscle reproduces features of myotonic dystrophy type 1. Ward AJ, Rimer M, Killian JM, Dowling JJ, & Cooper TA. Hum Mol Genet, 2010. PubMed

The pathobiology of alternative splicing. Ward AJ & Cooper TA. J Pathol, 2010. PubMed


2008

A postnatal switch of CELF and MBNL proteins reprograms alternative splicing in the developing heart. Kalsotra A, Xiao X, Ward AJ, Castle JC, Johnson JM, Burge CB, & Cooper TA. Proc Natl Acad Sci USA, 2008. PubMed